6VCB: Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator

PDB ID: 6VCBDownload
MMDB ID: 190412
PDB Deposition Date: 2019/12/20
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.3  Å
Source Organism:
Lama glama▼
Similar Structures:
Biological Unit for 6VCB: hexameric; determined by author
Molecular Components in 6VCB
Label Count Molecule
Proteins (6 molecules)
1
Glucagon-like Peptide 1 Receptor
Molecule annotation
1
Glucagon-like Peptide 1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Nanobody 35
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303