6V94: Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods

PDB ID: 6V94Download
MMDB ID: 191688
PDB Deposition Date: 2019/12/13
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 6V94: trimeric; determined by author and by software (PISA)
Molecular Components in 6V94
Label Count Molecule
Proteins (3 molecules)
1
Gtpase Hras
(Gene symbol: HRAS)
Molecule annotation
1
SON of Sevenless Homolog 1
(Gene symbol: SOS1)
Molecule annotation
1
Gtpase Hras
(Gene symbol: HRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
1
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
2
1
MAGNESIUM IONMAGNESIUM ION
3
1
1-[(4-fluorophenyl)methyl]-2-methyl-4-nitro-1H-imidazole1-[(4-fluorophenyl)methyl]-2-methyl-4-nitro-1H-imidazole
4
6
FORMIC ACIDFORMIC ACID
5
2
GLYCEROLGLYCEROL
6
1
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303