6UZA: Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473

PDB ID: 6UZADownload
MMDB ID: 185440
PDB Deposition Date: 2019/11/14
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.08  Å
Source Organism:
Similar Structures:
Biological Unit for 6UZA: tetrameric; determined by author
Molecular Components in 6UZA
Label Count Molecule
Proteins (4 molecules)
4
Short Transient Receptor Potential Channel 6
(Gene symbol: TRPC6)
Molecule annotation
Chemicals and Non-standard biopolymers (20 molecules)
1
4
4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile
2
4
2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium
3
4
[(2~{S})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-octanoyloxy-propan-2-yl] octadecanoate[(2~{S})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-octanoyloxy-propan-2-yl] octadecanoate
4
8
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303