6USF: CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5

PDB ID: 6USFDownload
MMDB ID: 187071
PDB Deposition Date: 2019/10/26
Updated in MMDB: 2020/05
Experimental Method:
electron microscopy
Resolution: 3.87  Å
Source Organism:
Similar Structures:
Biological Unit for 6USF: nonameric; determined by author
Molecular Components in 6USF
Label Count Molecule
Proteins (9 molecules)
2
Chimera of Soluble Cytochrome B562 (Bril) and Neuronal Acetylcholine Receptor Subunit Alpha-4
(Gene symbol: CHRNA4)
Molecule annotation
3
Neuronal Acetylcholine Receptor Subunit Beta-2
(Gene symbol: CHRNB2)
Molecule annotation
2
FAB Heavy Chain
Molecule annotation
2
FAB Light Chain
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
8
N-ACETYL-D-GLUCOSAMINEN-ACETYL-D-GLUCOSAMINE
2
2
VARENICLINEVARENICLINE
3
3
BETA-D-MANNOSEBETA-D-MANNOSE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303