6UOZ: Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction

PDB ID: 6UOZDownload
MMDB ID: 186473
PDB Deposition Date: 2019/10/16
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.532  Å
Source Organism:
Similar Structures:
Biological Unit for 6UOZ: dimeric; determined by author
Molecular Components in 6UOZ
Label Count Molecule
Proteins (2 molecules)
2
WD Repeat Domain 5
(Gene symbol: WDR5)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
5-bromo-3-chloro-N-[1-cyclopentyl-2-(methylsulfonyl)-1H-imidazol-4-yl]-2-hydroxybenzene-1-sulfonamide5-bromo-3-chloro-N-[1-cyclopentyl-2-(methylsulfonyl)-1H-imidazol-4-yl]-2-hydroxybenzene-1-sulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303