6UO8: Human metabotropic GABA(B) receptor bound to agonist SKF97541 and positive allosteric modulator GS39783

PDB ID: 6UO8Download
MMDB ID: 188761
PDB Deposition Date: 2019/10/14
Updated in MMDB: 2024/11
Experimental Method:
electron microscopy
Resolution: 3.63  Å
Source Organism:
Similar Structures:
Biological Unit for 6UO8: dimeric; determined by author
Molecular Components in 6UO8
Label Count Molecule
Proteins (2 molecules)
1
Gamma-aminobutyric Acid Type B Receptor Subunit 1
(Gene symbol: GABBR1)
Molecule annotation
1
Gamma-aminobutyric Acid Type B Receptor Subunit 2
(Gene symbol: GABBR2)
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
12
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranosebeta-D-mannopyranose
3
1
(R)-(3-aminopropyl)methylphosphinic acid(R)-(3-aminopropyl)methylphosphinic acid
4
1
N~4~,N~6~-dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamineN~4~,N~6~-dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303