6UML: Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex

PDB ID: 6UMLDownload
MMDB ID: 186472
PDB Deposition Date: 2019/10/9
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.58  Å
Source Organism:
Similar Structures:
Biological Unit for 6UML: trimeric; determined by author
Molecular Components in 6UML
Label Count Molecule
Proteins (3 molecules)
1
DNA Damage-binding Protein 1
(Gene symbol: DDB1)
Molecule annotation
1
Protein Cereblon
(Gene symbol: CRBN)
Molecule annotation
1
Sal-like Protein 4
(Gene symbol: SALL4)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
ZINC IONZINC ION
2
1
S-PomalidomideS-Pomalidomide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303