6U8L: Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction

PDB ID: 6U8LDownload
MMDB ID: 182001
PDB Deposition Date: 2019/9/5
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.57  Å
Source Organism:
Similar Structures:
Biological Unit for 6U8L: monomeric; determined by author and by software (PISA)
Molecular Components in 6U8L
Label Count Molecule
Protein (1 molecule)
1
WD Repeat-containing Protein 5
(Gene symbol: WDR5)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
3-{[(5-bromo-2-hydroxyphenyl)sulfonyl]amino}-5-cyclopropyl-6-fluoro-2-hydroxybenzoic acid3-{[(5-bromo-2-hydroxyphenyl)sulfonyl]amino}-5-cyclopropyl-6-fluoro-2-hydroxybenzoic acid
2
1
N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]isoquinolin-1-amineN-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]isoquinolin-1-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303