6U6C: Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form

PDB ID: 6U6CDownload
MMDB ID: 191898
PDB Deposition Date: 2019/8/29
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.402  Å
Source Organism:
Similar Structures:
Biological Unit for 6U6C: tetrameric; determined by author and by software (PISA)
Molecular Components in 6U6C
Label Count Molecule
Proteins (4 molecules)
2
Tryptophan Synthase Alpha Chain
(Gene symbol: trpA)
Molecule annotation
2
Tryptophan Synthase Beta Chain
(Gene symbol: trpB)
Molecule annotation
Chemicals and Non-standard biopolymers (78 molecules)
1
46
FORMIC ACIDFORMIC ACID
2
13
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
2
ACETATE IONACETATE ION
4
3
MALONATE IONMALONATE ION
5
2
1-(2-fluorobenzene-1-carbonyl)-N-methyl-2,3-dihydro-1H-indole-5-sulfonamide1-(2-fluorobenzene-1-carbonyl)-N-methyl-2,3-dihydro-1H-indole-5-sulfonamide
6
2
2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID
7
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
8
5
POTASSIUM IONPOTASSIUM ION
9
3
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
10
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303