6U38: PCSK9 in complex with a Fab and compound 8

PDB ID: 6U38Download
MMDB ID: 181164
PDB Deposition Date: 2019/8/21
Updated in MMDB: 2019/11
Experimental Method:
x-ray diffraction
Resolution: 2.73  Å
Source Organism:
Similar Structures:
Biological Unit for 6U38: tetrameric; determined by author
Molecular Components in 6U38
Label Count Molecule
Proteins (4 molecules)
2
Proprotein Convertase Subtilisin/kexin Type 9
(Gene symbol: PCSK9)
Molecule annotation
1
FAB Heavy Chain
Molecule annotation
1
FAB Light Chain
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-fluoro-4-{[(1R)-1-methyl-6-{[(2S)-oxan-2-yl]methoxy}-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid2-fluoro-4-{[(1R)-1-methyl-6-{[(2S)-oxan-2-yl]methoxy}-1-{2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}benzoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303