6U2O: Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink

PDB ID: 6U2ODownload
MMDB ID: 191676
PDB Deposition Date: 2019/8/20
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 6U2O: tetrameric; determined by author and by software (PISA)
Molecular Components in 6U2O
Label Count Molecule
Protein (1 molecule)
1
DNA Polymerase Beta
(Gene symbol: POLB)
Molecule annotation
Nucleotides(3 molecules)
1
DNA (5'-d(*cp*cp*cp*ap*cp*gp*gp*cp*cp*cp*ap*tp*cp*ap*cp*c)-3')
Molecule annotation
1
DNA (5'-d(*gp*gp*tp*gp*ap*tp*gp*gp*gp*c)-3')
Molecule annotation
1
DNA (5'-d(p*gp*tp*gp*gp*g)-3')
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
MAGNESIUM IONMAGNESIUM ION
2
2
SODIUM IONSODIUM ION
3
1
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine
4
1
CisplatinCisplatin
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303