6U0D: Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0590

PDB ID: 6U0DDownload
MMDB ID: 191378
PDB Deposition Date: 2019/8/14
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.43  Å
Source Organism:
Similar Structures:
Biological Unit for 6U0D: monomeric; determined by author and by software (PISA)
Molecular Components in 6U0D
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
2
1
N-[4-({(2S)-2-[(morpholin-4-yl)methyl]pyrrolidin-1-yl}sulfonyl)phenyl]-N'-[4-(trifluoromethyl)phenyl]ureaN-[4-({(2S)-2-[(morpholin-4-yl)methyl]pyrrolidin-1-yl}sulfonyl)phenyl]-N'-[4-(trifluoromethyl)phenyl]urea
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303