6TUY: Human LSD1/CoREST bound to the quinazoline inhibitor MC4106

PDB ID: 6TUYDownload
MMDB ID: 204618
PDB Deposition Date: 2020/1/8
Updated in MMDB: 2022/08
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 6TUY: dimeric; determined by author and by software (PISA)
Molecular Components in 6TUY
Label Count Molecule
Proteins (2 molecules)
1
Lysine-specific Histone Demethylase 1A
(Gene symbol: KDM1A)
Molecule annotation
1
Rest Corepressor 1
(Gene symbol: RCOR1)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
1
FLAVIN-ADENINE DINUCLEOTIDEFLAVIN-ADENINE DINUCLEOTIDE
2
3
~{N}2-[3-(dimethylamino)propyl]-6,7-dimethoxy-~{N}4-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]quinazoline-2,4-diamine~{N}2-[3-(dimethylamino)propyl]-6,7-dimethoxy-~{N}4-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]quinazoline-2,4-diamine
3
1
PHOSPHATE IONPHOSPHATE ION
4
5
CHLORIDE IONCHLORIDE ION
5
1
GLYCEROLGLYCEROL
6
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303