6TOS: Crystal structure of the Orexin-1 receptor in complex with GSK1059865

PDB ID: 6TOSDownload
MMDB ID: 183205
PDB Deposition Date: 2019/12/11
Updated in MMDB: 2020/03
Experimental Method:
x-ray diffraction
Resolution: 2.13  Å
Source Organism:
Similar Structures:
Biological Unit for 6TOS: monomeric; determined by author
Molecular Components in 6TOS
Label Count Molecule
Protein (1 molecule)
1
Orexin Receptor Type 1
(Gene symbol: HCRTR1)
Molecule annotation
Chemicals and Non-standard biopolymers (22 molecules)
1
1
[(2~{S},5~{S})-2-[[(5-bromanylpyridin-2-yl)amino]methyl]-5-methyl-piperidin-1-yl]-(3-fluoranyl-2-methoxy-phenyl)methanone[(2~{S},5~{S})-2-[[(5-bromanylpyridin-2-yl)amino]methyl]-5-methyl-piperidin-1-yl]-(3-fluoranyl-2-methoxy-phenyl)methanone
2
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
3
2
CITRIC ACIDCITRIC ACID
4
2
SULFATE IONSULFATE ION
5
13
octyl 1-thio-beta-D-glucopyranosideoctyl 1-thio-beta-D-glucopyranoside
6
1
SODIUM IONSODIUM ION
7
2
(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303