6T5J: Structure of NUDT15 in complex with inhibitor TH1760

PDB ID: 6T5JDownload
MMDB ID: 190598
PDB Deposition Date: 2019/10/16
Updated in MMDB: 2020/10
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 6T5J: dimeric; determined by author and by software (PISA)
Molecular Components in 6T5J
Label Count Molecule
Proteins (2 molecules)
2
Probable 8-oxo-dgtp Diphosphatase Nudt15
(Gene symbol: NUDT15)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
6-[4-(1~{H}-indol-5-ylcarbonyl)piperazin-1-yl]sulfonyl-3~{H}-1,3-benzoxazol-2-one6-[4-(1~{H}-indol-5-ylcarbonyl)piperazin-1-yl]sulfonyl-3~{H}-1,3-benzoxazol-2-one
2
4
MAGNESIUM IONMAGNESIUM ION
3
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303