6T2H: Furano[2,3-d]prymidine amides as Notum inhibitors

PDB ID: 6T2HDownload
MMDB ID: 182776
PDB Deposition Date: 2019/10/8
Updated in MMDB: 2024/01
Experimental Method:
x-ray diffraction
Resolution: 1.41  Å
Source Organism:
Similar Structures:
Biological Unit for 6T2H: monomeric; determined by author and by software (PISA)
Molecular Components in 6T2H
Label Count Molecule
Protein (1 molecule)
1
Palmitoleoyl-protein Carboxylesterase Notum
(Gene symbol: NOTUM)
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
2
7
SULFATE IONSULFATE ION
3
13
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
5
1
2-[[(4~{S})-5-chloranyl-6-methyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-4-yl]sulfanyl]ethanoic acid2-[[(4~{S})-5-chloranyl-6-methyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-4-yl]sulfanyl]ethanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303