6SKH: X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a inhibitor sulfamide inhibitor GluAsp

PDB ID: 6SKHDownload
MMDB ID: 191662
PDB Deposition Date: 2019/8/15
Updated in MMDB: 2020/08
Experimental Method:
x-ray diffraction
Resolution: 1.58  Å
Source Organism:
Similar Structures:
Biological Unit for 6SKH: dimeric; determined by author and by software (PISA)
Molecular Components in 6SKH
Label Count Molecule
Proteins (2 molecules)
2
Glutamate Carboxypeptidase 2
(Gene symbol: FOLH1)
Molecule annotation
Chemicals and Non-standard biopolymers (46 molecules)
1
20
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
2
beta-D-mannopyranosebeta-D-mannopyranose
3
2
alpha-D-mannopyranosealpha-D-mannopyranose
4
8
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
4
ZINC IONZINC ION
6
2
CALCIUM IONCALCIUM ION
7
2
CHLORIDE IONCHLORIDE ION
8
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
9
2
(2~{S})-2-[[(2~{S})-1,4-bis(oxidanyl)-1,4-bis(oxidanylidene)butan-2-yl]sulfamoylamino]pentanedioic acid(2~{S})-2-[[(2~{S})-1,4-bis(oxidanyl)-1,4-bis(oxidanylidene)butan-2-yl]sulfamoylamino]pentanedioic acid
10
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303