6SE4: Crystal Structure of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor

PDB ID: 6SE4Download
MMDB ID: 178549
PDB Deposition Date: 2019/7/29
Updated in MMDB: 2019/08
Experimental Method:
x-ray diffraction
Resolution: 1.38  Å
Source Organism:
Similar Structures:
Biological Unit for 6SE4: monomeric; determined by author and by software (PISA)
Molecular Components in 6SE4
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
(+)-JD1(+)-JD1
3
2
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303