6S4F: Structure of human MTHFD2 in complex with TH9619

PDB ID: 6S4FDownload
MMDB ID: 203928
PDB Deposition Date: 2019/6/27
Updated in MMDB: 2021/07
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 6S4F: dimeric; determined by author and by software (PISA)
Molecular Components in 6S4F
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase, Mitochondrial
(Gene symbol: MTHFD2)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
2
(E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid(E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid
2
8
PHOSPHATE IONPHOSPHATE ION
3
1
ADENOSINE-5'-DIPHOSPHATEADENOSINE-5'-DIPHOSPHATE
4
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303