6S4E: Structure of human MTHFD2 in complex with TH7299

PDB ID: 6S4EDownload
MMDB ID: 203927
PDB Deposition Date: 2019/6/27
Updated in MMDB: 2021/07
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 6S4E: dimeric; determined by author and by software (PISA)
Molecular Components in 6S4E
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase, Mitochondrial
(Gene symbol: MTHFD2)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
2
(2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid(2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid
2
8
PHOSPHATE IONPHOSPHATE ION
3
2
NICOTINAMIDE-ADENINE-DINUCLEOTIDENICOTINAMIDE-ADENINE-DINUCLEOTIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303