6S4A: Structure of human MTHFD2 in complex with TH9028

PDB ID: 6S4ADownload
MMDB ID: 203926
PDB Deposition Date: 2019/6/27
Updated in MMDB: 2021/07
Experimental Method:
x-ray diffraction
Resolution: 1.95  Å
Source Organism:
Similar Structures:
Biological Unit for 6S4A: dimeric; determined by author and by software (PISA)
Molecular Components in 6S4A
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase, Mitochondrial
(Gene symbol: MTHFD2)
Molecule annotation
Chemicals and Non-standard biopolymers (17 molecules)
1
2
(2~{S})-2-[[5-[[2,4-bis(azanyl)-6-oxidanylidene-5~{H}-pyrimidin-5-yl]carbamoylamino]pyridin-2-yl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid(2~{S})-2-[[5-[[2,4-bis(azanyl)-6-oxidanylidene-5~{H}-pyrimidin-5-yl]carbamoylamino]pyridin-2-yl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid
2
6
PHOSPHATE IONPHOSPHATE ION
3
2
NICOTINAMIDE-ADENINE-DINUCLEOTIDENICOTINAMIDE-ADENINE-DINUCLEOTIDE
4
7
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303