6S1X: X-ray structure of human glutamate carboxypeptidase II (GCPII)-E424M inactive mutant, in complex with a inhibitor KB1160

PDB ID: 6S1XDownload
MMDB ID: 187516
PDB Deposition Date: 2019/6/19
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 1.76  Å
Source Organism:
Similar Structures:
Biological Unit for 6S1X: dimeric; determined by author and by software (PISA)
Molecular Components in 6S1X
Label Count Molecule
Proteins (2 molecules)
2
Glutamate Carboxypeptidase 2
(Gene symbol: FOLH1)
Molecule annotation
Chemicals and Non-standard biopolymers (34 molecules)
1
20
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
beta-D-mannopyranosebeta-D-mannopyranose
3
1
alpha-D-mannopyranosealpha-D-mannopyranose
4
4
ZINC IONZINC ION
5
2
CALCIUM IONCALCIUM ION
6
2
CHLORIDE IONCHLORIDE ION
7
2
(2~{S})-2-[[(3~{S})-3-[3-[(4-iodophenyl)carbonylamino]propanoylamino]-4-oxidanyl-4-oxidanylidene-butyl]carbamoylamino]pentanedioic acid(2~{S})-2-[[(3~{S})-3-[3-[(4-iodophenyl)carbonylamino]propanoylamino]-4-oxidanyl-4-oxidanylidene-butyl]carbamoylamino]pentanedioic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303