6S1J: Crystal Structure of DYRK1A with small molecule inhibitor

PDB ID: 6S1JDownload
MMDB ID: 176890
PDB Deposition Date: 2019/6/18
Updated in MMDB: 2019/08
Experimental Method:
x-ray diffraction
Resolution: 1.408  Å
Source Organism:
Similar Structures:
Biological Unit for 6S1J: monomeric; determined by author and by software (PISA)
Molecular Components in 6S1J
Label Count Molecule
Protein (1 molecule)
1
Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A
(Gene symbol: DYRK1A)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
1
3-[2-[(3~{S})-3-fluoranylpyrrolidin-1-yl]pyrimidin-4-yl]pyrazolo[1,5-b]pyridazine3-[2-[(3~{S})-3-fluoranylpyrrolidin-1-yl]pyrimidin-4-yl]pyrazolo[1,5-b]pyridazine
2
6
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
4
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303