6S1I: Crystal Structure of DYRK1A with small molecule inhibitor

PDB ID: 6S1IDownload
MMDB ID: 176889
PDB Deposition Date: 2019/6/18
Updated in MMDB: 2021/08
Experimental Method:
x-ray diffraction
Resolution: 2.38  Å
Source Organism:
Similar Structures:
Biological Unit for 6S1I: monomeric; determined by author
Molecular Components in 6S1I
Label Count Molecule
Protein (1 molecule)
1
Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A
(Gene symbol: DYRK1A)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
SULFATE IONSULFATE ION
2
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
3
1
~{N}-methyl-~{N}-phenyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine~{N}-methyl-~{N}-phenyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303