6S17: Crystal Structure of DYRK1A with small molecule inhibitor

PDB ID: 6S17Download
MMDB ID: 176886
PDB Deposition Date: 2019/6/18
Updated in MMDB: 2019/08
Experimental Method:
x-ray diffraction
Resolution: 1.1  Å
Source Organism:
Similar Structures:
Biological Unit for 6S17: monomeric; determined by software (PISA)
Molecular Components in 6S17
Label Count Molecule
Protein (1 molecule)
1
Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A
(Gene symbol: DYRK1A)
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
3
SULFATE IONSULFATE ION
2
7
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
~{N},~{N}-dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine~{N},~{N}-dimethyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303