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6S14:
Crystal Structure of DYRK1A with small molecule inhibitor
PDB ID:
6S14
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MMDB ID:
176885
PDB Deposition Date:
2019/6/18
Updated in MMDB:
2019/08
Experimental Method:
x-ray diffraction
Resolution:
1.05 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 6S14: monomeric; determined by author and by software (PISA)
Molecular Components in 6S14
Label
Count
Molecule
Protein (1 molecule)
A
1
Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A
(Gene symbol:
DYRK1A
)
Chemicals and Non-standard biopolymers (7 molecules)
1
6
SULFATE ION
2
1
~{N}-cyclopropyl-~{N}-methyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303