6RFN: Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1018

PDB ID: 6RFNDownload
MMDB ID: 177813
PDB Deposition Date: 2019/4/15
Updated in MMDB: 2019/09
Experimental Method:
x-ray diffraction
Resolution: 2.29  Å
Source Organism:
Similar Structures:
Biological Unit for 6RFN: monomeric; determined by author
Molecular Components in 6RFN
Label Count Molecule
Protein (1 molecule)
1
Phosphodiesterase
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
ZINC IONZINC ION
2
1
MAGNESIUM IONMAGNESIUM ION
3
2
FORMIC ACIDFORMIC ACID
4
3
GUANIDINEGUANIDINE
5
1
GLYCEROLGLYCEROL
6
1
3-[5-[(4~{a}~{R},8~{a}~{S})-4-oxidanylidene-3-propan-2-yl-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-~{N}-(3-methoxyphenyl)prop-2-ynamide3-[5-[(4~{a}~{R},8~{a}~{S})-4-oxidanylidene-3-propan-2-yl-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-~{N}-(3-methoxyphenyl)prop-2-ynamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303