6QUX: Crystal Structure of KRAS-G12D in Complex with Natural Product-Like Compound 15

PDB ID: 6QUXDownload
MMDB ID: 178064
PDB Deposition Date: 2019/2/28
Updated in MMDB: 2019/09
Experimental Method:
x-ray diffraction
Resolution: 1.62  Å
Source Organism:
Similar Structures:
Biological Unit for 6QUX: dimeric; determined by author and by software (PISA)
Molecular Components in 6QUX
Label Count Molecule
Proteins (2 molecules)
2
Gtpase Kras
(Gene symbol: KRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
2
PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTERPHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
2
2
MAGNESIUM IONMAGNESIUM ION
3
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
(6~{a}~{R},11~{b}~{S})-6~{a}-(1,4-dimethylpiperidin-4-yl)-7,11~{b}-dihydro-6~{H}-indolo[2,3-c]isoquinolin-5-one(6~{a}~{R},11~{b}~{S})-6~{a}-(1,4-dimethylpiperidin-4-yl)-7,11~{b}-dihydro-6~{H}-indolo[2,3-c]isoquinolin-5-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303