6Q6O: RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 2 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors

PDB ID: 6Q6ODownload
MMDB ID: 181763
PDB Deposition Date: 2018/12/11
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 6Q6O: monomeric; determined by author and by software (PISA)
Molecular Components in 6Q6O
Label Count Molecule
Protein (1 molecule)
1
Nuclear Receptor Ror-gamma
(Gene symbol: RORC)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
propan-2-yl (2~{S})-2-[[2,6-bis(chloranyl)phenyl]-(furan-2-ylcarbonyl)amino]propanoatepropan-2-yl (2~{S})-2-[[2,6-bis(chloranyl)phenyl]-(furan-2-ylcarbonyl)amino]propanoate
2
2
CHOLIC ACIDCHOLIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303