6PT0: Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2

PDB ID: 6PT0Download
MMDB ID: 184106
PDB Deposition Date: 2019/7/14
Updated in MMDB: 2024/12
Experimental Method:
electron microscopy
Resolution: 3.2  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 6PT0: pentameric; determined by author
Molecular Components in 6PT0
Label Count Molecule
Proteins (5 molecules)
1
Cannabinoid Receptor 2
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Scfv16
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
{(3R)-5-methyl-3-[(morpholin-4-yl)methyl]-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl}(naphthalen-1-yl)methanone{(3R)-5-methyl-3-[(morpholin-4-yl)methyl]-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl}(naphthalen-1-yl)methanone
2
4
PALMITIC ACIDPALMITIC ACID
3
4
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303