6PQO: Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010

PDB ID: 6PQODownload
MMDB ID: 182918
PDB Deposition Date: 2019/7/9
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 2.88  Å
Source Organism:
Similar Structures:
Biological Unit for 6PQO: tetrameric; determined by author
Molecular Components in 6PQO
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily a Member 1
(Gene symbol: TRPA1)
Molecule annotation
Chemicals and Non-standard biopolymers (36 molecules)
1
8
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide
3
8
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
4
16
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303