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6PF7:
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)benzoic acid
PDB ID:
6PF7
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MMDB ID:
180082
PDB Deposition Date:
2019/6/21
Updated in MMDB:
2019/12
Experimental Method:
x-ray diffraction
Resolution:
2.795 Å
Source Organism:
Cryptosporidium hominis
Similar Structures:
VAST+
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Biological Unit for 6PF7: dimeric; determined by author and by software (PISA)
Molecular Components in 6PF7
Label
Count
Molecule
Proteins (2 molecules)
A
B
2
Bifunctional Dihydrofolate Reductase-thymidylate Synthase
Chemicals and Non-standard biopolymers (10 molecules)
1
2
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
2
5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE
3
2
2-({4-[(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzoic acid
4
2
METHOTREXATE
5
2
SULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303