6PAF: Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors

PDB ID: 6PAFDownload
MMDB ID: 183121
PDB Deposition Date: 2019/6/11
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.241  Å
Source Organism:
Similar Structures:
Biological Unit for 6PAF: monomeric; determined by author and by software (PISA)
Molecular Components in 6PAF
Label Count Molecule
Protein (1 molecule)
1
Histone-lysine N-methyltransferase Smyd3
(Gene symbol: SMYD3)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
3
ZINC IONZINC ION
2
2
MAGNESIUM IONMAGNESIUM ION
3
2
GLYCEROLGLYCEROL
4
1
S-ADENOSYLMETHIONINES-ADENOSYLMETHIONINE
5
1
N-(1-{[4-(aminomethyl)phenyl]sulfonyl}piperidin-4-yl)-5-cyclopropyl-1,2-oxazole-3-carboxamideN-(1-{[4-(aminomethyl)phenyl]sulfonyl}piperidin-4-yl)-5-cyclopropyl-1,2-oxazole-3-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303