NCBI
National Center for
Biotechnology Information
Search
6P8X:
Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor
PDB ID:
6P8X
Download
MMDB ID:
178921
PDB Deposition Date:
2019/6/8
Updated in MMDB:
2019/10
Experimental Method:
x-ray diffraction
Resolution:
2.11 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 6P8X: monomeric; determined by author and by software (PISA)
Molecular Components in 6P8X
Label
Count
Molecule
Protein (1 molecule)
A
1
Gtpase Kras
(Gene symbol:
KRAS
)
Chemicals and Non-standard biopolymers (6 molecules)
1
3
CALCIUM ION
2
1
GUANOSINE-5'-DIPHOSPHATE
3
2
2-[4-bromo-2-(3-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl)phenoxy]-N-(1-propanoylazetidin-3-yl)acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303