6P8X: Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor

PDB ID: 6P8XDownload
MMDB ID: 178921
PDB Deposition Date: 2019/6/8
Updated in MMDB: 2019/10
Experimental Method:
x-ray diffraction
Resolution: 2.11  Å
Source Organism:
Similar Structures:
Biological Unit for 6P8X: monomeric; determined by author and by software (PISA)
Molecular Components in 6P8X
Label Count Molecule
Protein (1 molecule)
1
Gtpase Kras
(Gene symbol: KRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
3
CALCIUM IONCALCIUM ION
2
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
3
2
2-[4-bromo-2-(3-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl)phenoxy]-N-(1-propanoylazetidin-3-yl)acetamide2-[4-bromo-2-(3-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl)phenoxy]-N-(1-propanoylazetidin-3-yl)acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303