6P8Q: EGFR in complex with a dihydrodibenzodiazepinone allosteric inhibitor

PDB ID: 6P8QDownload
MMDB ID: 182351
PDB Deposition Date: 2019/6/7
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 6P8Q: dimeric; determined by author and by software (PISA)
Molecular Components in 6P8Q
Label Count Molecule
Proteins (2 molecules)
2
Epidermal Growth Factor Receptor
(Gene symbol: EGFR)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
2
2
10-benzyl-2-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one10-benzyl-2-fluoro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
3
3
MAGNESIUM IONMAGNESIUM ION
4
1
ADENOSINE MONOPHOSPHATEADENOSINE MONOPHOSPHATE
5
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303