6O0L: crystal structure of BCL-2 G101V mutation with venetoclax

PDB ID: 6O0LDownload
MMDB ID: 175652
PDB Deposition Date: 2019/2/16
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
Similar Structures:
Biological Unit for 6O0L: monomeric; determined by author and by software (PISA)
Molecular Components in 6O0L
Label Count Molecule
Protein (1 molecule)
1
Apoptosis Regulator Bcl-2,bcl-2-like Protein 1,apoptosis Regulator Bcl-2
(Gene symbol: BCL2)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl)methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
2
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
3
1
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303