6NY0: Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a bisbenzimidazole inhibitor

PDB ID: 6NY0Download
MMDB ID: 175861
PDB Deposition Date: 2019/2/10
Updated in MMDB: 2019/09
Experimental Method:
x-ray diffraction
Resolution: 1.4  Å
Source Organism:
Similar Structures:
Biological Unit for 6NY0: tetrameric; determined by author and by software (PISA)
Molecular Components in 6NY0
Label Count Molecule
Proteins (4 molecules)
4
Dihydrofolate Reductase Type 2
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
3
2-(4-{3-[4-(6-carboxy-1H-benzimidazol-2-yl)phenoxy]-2-hydroxypropoxy}phenyl)-1H-benzimidazole-5-carboxylic acid2-(4-{3-[4-(6-carboxy-1H-benzimidazol-2-yl)phenoxy]-2-hydroxypropoxy}phenyl)-1H-benzimidazole-5-carboxylic acid
2
8
(4R)-2-METHYLPENTANE-2,4-DIOL(4R)-2-METHYLPENTANE-2,4-DIOL
3
8
PHOSPHATE IONPHOSPHATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303