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6NE5:
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer
PDB ID:
6NE5
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MMDB ID:
174430
PDB Deposition Date:
2018/12/17
Updated in MMDB:
2019/12
Experimental Method:
x-ray diffraction
Resolution:
1.85 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Biological Unit for 6NE5: monomeric; determined by author and by software (PISA)
Molecular Components in 6NE5
Label
Count
Molecule
Protein (1 molecule)
A
1
Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1
(Gene symbol:
MCL1
)
Chemicals and Non-standard biopolymers (2 molecules)
1
2
3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-1H-indole-5-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303