6N6O: Crystal structure of the human TTK in complex with an inhibitor

PDB ID: 6N6ODownload
MMDB ID: 175442
PDB Deposition Date: 2018/11/26
Updated in MMDB: 2019/06
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 6N6O: monomeric; determined by author and by software (PISA)
Molecular Components in 6N6O
Label Count Molecule
Protein (1 molecule)
1
Dual Specificity Protein Kinase TTK
(Gene symbol: TTK)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
4-({5-chloro-4-[(cis-4-hydroxy-4-methylcyclohexyl)oxy]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)-N,N-dimethyl-3-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}benzamide4-({5-chloro-4-[(cis-4-hydroxy-4-methylcyclohexyl)oxy]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)-N,N-dimethyl-3-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}benzamide
2
1
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
3
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303