6N3N: Identification of novel, potent and selective GCN2 inhibitors as first-in-class anti-tumor agents

PDB ID: 6N3NDownload
MMDB ID: 180290
PDB Deposition Date: 2018/11/15
Updated in MMDB: 2019/10
Experimental Method:
x-ray diffraction
Resolution: 3.01  Å
Source Organism:
Similar Structures:
Biological Unit for 6N3N: monomeric; determined by author and by software (PISA)
Molecular Components in 6N3N
Label Count Molecule
Protein (1 molecule)
1
Eif-2-alpha Kinase Gcn2,eif-2-alpha Kinase Gcn2
(Gene symbol: EIF2AK4)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-2,5-dichloro-3-(hydroxymethyl)benzene-1-sulfonamideN-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-2,5-dichloro-3-(hydroxymethyl)benzene-1-sulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303