6N3L: Identification of novel, potent and selective GCN2 inhibitors as first-in-class anti-tumor agents

PDB ID: 6N3LDownload
MMDB ID: 180289
PDB Deposition Date: 2018/11/15
Updated in MMDB: 2019/10
Experimental Method:
x-ray diffraction
Resolution: 2.61  Å
Source Organism:
Similar Structures:
Biological Unit for 6N3L: monomeric; determined by author and by software (PISA)
Molecular Components in 6N3L
Label Count Molecule
Protein (1 molecule)
1
Eif-2-alpha Kinase Gcn2,eif-2-alpha Kinase Gcn2
(Gene symbol: EIF2AK4)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-{6-[(1-methyl-2-{[4-(trifluoromethyl)phenyl]amino}-1H-benzimidazol-5-yl)oxy]pyrimidin-4-yl}cyclopropanecarboxamideN-{6-[(1-methyl-2-{[4-(trifluoromethyl)phenyl]amino}-1H-benzimidazol-5-yl)oxy]pyrimidin-4-yl}cyclopropanecarboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303