6MK0: Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161

PDB ID: 6MK0Download
MMDB ID: 180799
PDB Deposition Date: 2018/9/24
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 3.005  Å
Source Organism:
Similar Structures:
Biological Unit for 6MK0: dimeric; determined by author and by software (PISA)
Molecular Components in 6MK0
Label Count Molecule
Proteins (2 molecules)
1
Integrin Alpha-v
(Gene symbol: ITGAV)
Molecule annotation
1
Integrin Beta-3
(Gene symbol: ITGB3)
Molecule annotation
Chemicals and Non-standard biopolymers (34 molecules)
1
20
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
3
beta-D-mannopyranosebeta-D-mannopyranose
3
2
alpha-D-mannopyranosealpha-D-mannopyranose
4
8
MANGANESE (II) IONMANGANESE (II) ION
5
1
(2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1,8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid(2S)-2-[(1,3-benzothiazole-2-carbonyl)amino]-4-{[5-(1,8-naphthyridin-2-yl)pentanoyl]amino}butanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303