6MEP: Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC3437

PDB ID: 6MEPDownload
MMDB ID: 179303
PDB Deposition Date: 2018/9/6
Updated in MMDB: 2019/10
Experimental Method:
x-ray diffraction
Resolution: 2.893  Å
Source Organism:
Similar Structures:
Biological Unit for 6MEP: dimeric; determined by author and by software (PISA)
Molecular Components in 6MEP
Label Count Molecule
Proteins (2 molecules)
2
Tyrosine-protein Kinase MER
(Gene symbol: MERTK)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
5
CHLORIDE IONCHLORIDE ION
2
2
cis-4-[(2-[(4-{[4-(1,3-dioxolan-2-yl)pyridin-2-yl]ethynyl}phenyl)amino]-5-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}pyrimidin-4-yl)amino]cyclohexan-1-olcis-4-[(2-[(4-{[4-(1,3-dioxolan-2-yl)pyridin-2-yl]ethynyl}phenyl)amino]-5-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}pyrimidin-4-yl)amino]cyclohexan-1-ol
3
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303