6LS4: A novel anti-tumor agent S-40 in complex with tubulin

PDB ID: 6LS4Download
MMDB ID: 197635
PDB Deposition Date: 2020/1/17
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 6LS4: pentameric; determined by author and by software (PISA)
Molecular Components in 6LS4
Label Count Molecule
Proteins (5 molecules)
2
Tubulin Alpha-1b Chain
(Gene symbol: TUBA1B)
Molecule annotation
2
Tubulin Beta Chain
Molecule annotation
1
Stathmin
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
3
GUANOSINE-5'-TRIPHOSPHATEGUANOSINE-5'-TRIPHOSPHATE
2
6
MAGNESIUM IONMAGNESIUM ION
3
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
4
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
5
1
GLYCEROLGLYCEROL
6
2
3-[(4-cyclopropylphenyl)sulfonylamino]-4-methyl-N-(pyridin-3-ylmethyl)benzamide3-[(4-cyclopropylphenyl)sulfonylamino]-4-methyl-N-(pyridin-3-ylmethyl)benzamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303