6LP8: Crystal structure of human DHODH in complex with inhibitor 1243

PDB ID: 6LP8Download
MMDB ID: 193343
PDB Deposition Date: 2020/1/9
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.79  Å
Source Organism:
Similar Structures:
Biological Unit for 6LP8: monomeric; determined by author and by software (PISA)
Molecular Components in 6LP8
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase (Quinone), Mitochondrial
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
2
1
OROTIC ACIDOROTIC ACID
3
2
SULFATE IONSULFATE ION
4
5
ACETATE IONACETATE ION
5
1
LAURYL DIMETHYLAMINE-N-OXIDELAURYL DIMETHYLAMINE-N-OXIDE
6
1
3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione
7
3
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303