6LKE: in meso full-length rat KMO in complex with an inhibitor identified via DNA-encoded chemical library screening

PDB ID: 6LKEDownload
MMDB ID: 196692
PDB Deposition Date: 2019/12/19
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 3  Å
Source Organism:
Similar Structures:
Biological Unit for 6LKE: dimeric; determined by author
Molecular Components in 6LKE
Label Count Molecule
Proteins (2 molecules)
2
Kynurenine 3-monooxygenase
(Gene symbol: Kmo)
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
2
FLAVIN-ADENINE DINUCLEOTIDEFLAVIN-ADENINE DINUCLEOTIDE
2
2
SULFATE IONSULFATE ION
3
2
CHLORIDE IONCHLORIDE ION
4
2
4-chloranyl-2-[[5-chloranyl-2-(5-methoxy-1,3-dihydroisoindol-2-yl)-1,3-thiazol-4-yl]carbonyl-methyl-amino]-5-fluoranyl-benzoic acid4-chloranyl-2-[[5-chloranyl-2-(5-methoxy-1,3-dihydroisoindol-2-yl)-1,3-thiazol-4-yl]carbonyl-methyl-amino]-5-fluoranyl-benzoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303