6LEH: Crystal structure of Autotaxin in complex with an inhibitor

PDB ID: 6LEHDownload
MMDB ID: 185259
PDB Deposition Date: 2019/11/25
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 6LEH: monomeric; determined by author and by software (PISA)
Molecular Components in 6LEH
Label Count Molecule
Protein (1 molecule)
1
Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member 2
(Gene symbol: Enpp2)
Molecule annotation
Chemicals and Non-standard biopolymers (35 molecules)
1
4
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
5
alpha-D-mannopyranosealpha-D-mannopyranose
3
2
ZINC IONZINC ION
4
1
CALCIUM IONCALCIUM ION
5
1
SODIUM IONSODIUM ION
6
1
POTASSIUM IONPOTASSIUM ION
7
1
SULFATE IONSULFATE ION
8
2
CHLORIDE IONCHLORIDE ION
9
17
1,2-ETHANEDIOL1,2-ETHANEDIOL
10
1
ethyl 2-[2-(4-chlorophenyl)-7-methyl-5-oxidanylidene-imidazo[1,2-a]pyrimidin-8-yl]ethanoateethyl 2-[2-(4-chlorophenyl)-7-methyl-5-oxidanylidene-imidazo[1,2-a]pyrimidin-8-yl]ethanoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303