6L3X: Discovery of novel peptidomimetic boronate ClpP inhibitors with noncanonical enzyme mechanism as potent virulence blockers in vitro and in vivo

PDB ID: 6L3XDownload
MMDB ID: 191571
PDB Deposition Date: 2019/10/15
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.3054  Å
Source Organism:
Similar Structures:
Biological Unit for 6L3X: 14-meric; determined by author and by software (PISA)
Molecular Components in 6L3X
Label Count Molecule
Proteins (14 molecules)
14
Atp-dependent CLP Protease Proteolytic Subunit
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
14
[(1~{R})-1-[[(2~{S})-2-[[2,5-bis(chloranyl)phenyl]carbonylamino]-3-(1~{H}-indol-3-yl)propanoyl]amino]-3-methyl-butyl]boronic acid[(1~{R})-1-[[(2~{S})-2-[[2,5-bis(chloranyl)phenyl]carbonylamino]-3-(1~{H}-indol-3-yl)propanoyl]amino]-3-methyl-butyl]boronic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303