6JWZ: Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613S triple mutant with SDX-DHP

PDB ID: 6JWZDownload
MMDB ID: 184037
PDB Deposition Date: 2019/4/21
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.95  Å
Source Organism:
Similar Structures:
Biological Unit for 6JWZ: dimeric; determined by author and by software (PISA)
Molecular Components in 6JWZ
Label Count Molecule
Proteins (2 molecules)
2
7,8-dihydro-6-hydroxymethylpterin Pyrophosphokinase-dihydropteroate Synthase
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
2
4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide4-[(2-azanyl-4-oxidanylidene-7,8-dihydro-3~{H}-pteridin-6-yl)methylamino]-~{N}-(5,6-dimethoxypyrimidin-4-yl)benzenesulfonamide
2
2
PHOSPHATE IONPHOSPHATE ION
3
2
ADENOSINE MONOPHOSPHATEADENOSINE MONOPHOSPHATE
4
2
MAGNESIUM IONMAGNESIUM ION
5
2
CALCIUM IONCALCIUM ION
6
2
ACETATE IONACETATE ION
7
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303