6JME: Crystal structure of human DHODH in complex with inhibitor 0946

PDB ID: 6JMEDownload
MMDB ID: 185219
PDB Deposition Date: 2019/3/8
Updated in MMDB: 2020/10
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 6JME: monomeric; determined by author and by software (PISA)
Molecular Components in 6JME
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase (Quinone), Mitochondrial
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
2
1
OROTIC ACIDOROTIC ACID
3
3
SULFATE IONSULFATE ION
4
3
ACETATE IONACETATE ION
5
1
LAURYL DIMETHYLAMINE-N-OXIDELAURYL DIMETHYLAMINE-N-OXIDE
6
1
3-[3,5-bis(fluoranyl)-4-(2-fluorophenyl)phenyl]benzo[f]benzotriazole-4,9-dione3-[3,5-bis(fluoranyl)-4-(2-fluorophenyl)phenyl]benzo[f]benzotriazole-4,9-dione
7
3
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303